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An analogue computer model for the insulin response to glucose infusion

The Department of Endocrinology and Metabolism, Karolinska Hospital, and the Division for Guidance and Control Theory, Research Institute of National Defence, Stockholm

Bertil Andersson

The Department of Endocrinology and Metabolism, Karolinska Hospital, and the Division for Guidance and Control Theory, Research Institute of National Defence, Stockholm

An analogue computer model has been constructed for the analysis of the interrelationship between blood glucose and plasma insulin concentrations during glucose infusion. The model presented gives quantitative information on the effect of plasma insulin on glucose uptake, the total amount of glucose taken up by the tissues at a given time, the effect of blood glucose on the release of stored and newly formed insulin, and the rapidity by which plasma insulin is increased in response to hyperglycaemia.

Such an analogue computer model might be a useful tool in the investigation of the various dynamic factors involved in the glucose- insulin interrelationship.

SIMULATION, Vol. 16, No. 6, 243-255 (1971)
DOI: 10.1177/003754977101600601


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