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Exploration of a Menstrual Cycle Model

Purdue University

This paper reports on the exploration and use of a sim ulation of the human menstrual cycle published in the July 1972 (Vol. 35, No. 1) issue of The Journal of Clinical Endo crinology & Metabolism by R. J. Bogumil, M. Ferin, J. Rootenberg, L. Speroff, and R. L. Vande Wiele. The simula tion appears to duplicate well the cyclic hormonal fluc tuations of a normally ovulating woman. But when asked to duplicate the results of giving a woman exogenous es tradiol, the simulation produces results which are in dis agreement with other published research data. Extrapo lation from the reported simulation beyond the normal undisturbed cycle produced results that do not agree with published physiological data, suggesting that the model needs further refinement. However, simulations run using the model indicate the possibility of stopping the menstrual cycle by a properly timed application of the hor mone estradiol (E2).

SIMULATION, Vol. 24, No. 2, 117-120 (1975)
DOI: 10.1177/003754977502400203


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