Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
SIMULATION
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Alberghina, L.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Modeling the control of cell growth

Lilia Alberghina

Laboratory of Comparative Biochemistry Institute of Physiology and Biochemistry University of Milan Via C. Saldini 50 20133 Milan, Italy

Cell growth and proliferation are biological phenomena that have not yet been explained. This paper shows how models of the biochemical processes involved can be used both to interpret existing data and to design new experiments. A model is presented that divides the cell into two subsystems: one that synthesizes ribosomes and proteins and a second that performs DNA replication and cell division. Data obtained by simulation, as well as the analytical solution of the model equations, indicate that it is the activity of the first subsystem (the one whose state variables are ribosomes and proteins) and not that of the subsystem that limits the rate of cell proliferation.

Key Words: biology • cancer • cell kinetics • DNA • growth regulation • protein • ribosomes

SIMULATION, Vol. 31, No. 2, 37-41 (1978)
DOI: 10.1177/003754977803100202
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?