Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
SIMULATION
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Charkes, N. D.
Right arrow Articles by Bove, A. A.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

A multicompartmental model which simulates the Thallium-201 exercise stress test

N. David Charkes

Departments of Nuclear Medicine (NDC,JAS,AHM,CH) and Cardiology (CH,AAB). Temple University Medical School and Hospital, 3401 N. Broad Street, Philadelphia, PA 19140

Jeffrey A. Siegel

Departments of Nuclear Medicine (NDC,JAS,AHM,CH) and Cardiology (CH,AAB). Temple University Medical School and Hospital, 3401 N. Broad Street, Philadelphia, PA 19140

Alan H. Maurer

Departments of Nuclear Medicine (NDC,JAS,AHM,CH) and Cardiology (CH,AAB). Temple University Medical School and Hospital, 3401 N. Broad Street, Philadelphia, PA 19140

Christopher Hansen

Departments of Nuclear Medicine (NDC,JAS,AHM,CH) and Cardiology (CH,AAB). Temple University Medical School and Hospital, 3401 N. Broad Street, Philadelphia, PA 19140

Alfred A. Bove

Departments of Nuclear Medicine (NDC,JAS,AHM,CH) and Cardiology (CH,AAB). Temple University Medical School and Hospital, 3401 N. Broad Street, Philadelphia, PA 19140

Thallium-201 exercise stress testing is a standard method of identifiying ischemia of coronary artery disease, but no model exists for simulating the test. We have developed such a model using compartmental analysis methods. Blood samples were obtained from resting dogs following IV Tl-201 adminis tration, and fitted by a sum of four exponentials, indicative of a four compart ment system. The intercompartmental rate constants were estimated from fitting blood, heart and urinary excretion data using a table top computer; a best fit was obtained by non-linear least squares regression. By partitioning the heart into normal flow and ischemic zones, the effects of varying blood flow during treadmill exercise could be simulated, by summing resting flow and increased flow whose duration was varied by a damping circuit and delay line. Progressively decreasing flow in the perturbed model reproduced the abnormal Tl-201 distribution seen clinically by scanning, and experimentally. This model appears to be a useful simulation of the Tl- 201 exercise stress test.

Key Words: Thallium-201 • stress test • radioisotopes • compartmental model ing • simulation

SIMULATION, Vol. 59, No. 1, 7-12 (1992)
DOI: 10.1177/003754979205900104
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?