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SIMULATION, Vol. 6, No. 4, 266-271 (1966)
DOI: 10.1177/003754976600600410

Analog computer simulation of abnormal periodic breathing

Howard T. Milhorn, JR

Department of Physiology and Biophysics University of Mississippi Medical Center Jackson, Mississippi

Arthur C. Guyton

Department of Physiology and Biophysics University of Mississippi Medical Center Jackson, Mississippi

The human respiratory system is compared to a techno logical feedback control system. Oscillation of the tech nological system is discussed and related to abnormal oscillation of human respiration (Cheyne-Stokes breath ing). A mathematical model of the human respiratory control system, utilizing CO 2 control of respiration only, is derived and programmed on an analog computer. The resulting computer study has shown that, as in the tech nological system, an increase of open-loop gain and/or delay time around the open loop can cause the respiratory system to become unstable and oscillate in an abnormal manner.


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